Inhibitor-Resistant OXY-2-Derived β-Lactamase Produced by Klebsiella oxytoca

Inhibitor-resistant OXY-2-derived beta-lactamase produced by Klebsiella oxytoca.

Klebsiella oxytoca strains are generally moderately resistant to amoxicillin and ticarcillin due to the activities of the chromosomally encoded OXY-1 and OXY-2 class A beta-lactamase families. These enzymes have the ability to hydrolyze not only penicillins but also cephalosporins, including cefuroxime, ceftriaxone, and aztreonam, and are inhibited by clavulanic acid. A Klebsiella oxytoca strai...

Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

We investigated a Klebsiella oxytoca isolate demonstrating resistance to imipenem, meropenem, extended-spectrum cephalosporins, and aztreonam. The MICs of both imipenem and meropenem were 32 microg/ml. The beta-lactamase activity against imipenem and meropenem was inhibited in the presence of clavulanic acid. Isoelectric focusing studies demonstrated five beta-lactamases with pIs of 8.2 (SHV-46...

Carbapenem-Resistant Strain of Klebsiella oxytoca Harboring Carbapenem-Hydrolyzing -Lactamase KPC-2

Carbapenem-Resistant Strain of Klebsiella oxytoca Harboring Carbapenem-Hydrolyzing -Lactamase KPC-2 Hesna Yigit, Anne Marie Queenan, J. Kamile Rasheed, James W. Biddle, Antonio Domenech-Sanchez, Sebastian Alberti, Karen Bush, and Fred C. Tenover* Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492; The R. W. Johnson Pharmaceutical Research Institute, Raritan, ...

Outbreak of Extended-Spectrum β-Lactamase–producing Klebsiella oxytoca Infections Associated with Contaminated Handwashing Sinks1

Klebsiella oxytoca is primarily a health care-associated pathogen acquired from environmental sources. During October 2006-March 2011, a total of 66 patients in a hospital in Toronto, Ontario, Canada, acquired class A extended-spectrum β-lactamase-producing K. oxytoca with 1 of 2 related pulsed-field gel electrophoresis patterns. New cases continued to occur despite reinforcement of infection c...

Outbreak of OXY - 2 producing - Klebsiella oxytoca in a renal transplant unit . 1 2 Running Title : Klebsiella oxytoca outbreak in a transplant unit 3 4